genetic heterogeneities การใช้

• Six families did not link to either locus, indicating genetic heterogeneity.
• Genetic Heterogeneity is responsible for the presence of many medical disorders in humans.
• This is an example of allelic genetic heterogeneity.
• Genetic heterogeneity is present in many disorders.
• Recent blood and DNA studies of present-day populations in Central Asia confirm the extreme genetic heterogeneity.
• The participants are all Ashkenazi Jews, a group selected for their genetic heterogeneity, which makes it easier to identify significant genetic variations.
• Mitochondrial complex I deficiency shows extreme genetic heterogeneity and can be caused by mutation in nuclear-encoded genes or in mitochondrial-encoded genes.
• Molecular genetic testing by linkage analysis or direct mutation screening is clinically available; however, genetic heterogeneity is a significant complication to molecular genetic testing.
• The latest DNA studies on Turkic people in Central Asia and Eastern Europe also confirm genetic heterogeneity, indicating that the Turkic tribal confederations included various haplogroups.
• Genetic heterogeneity within individual is indeed usually considered to be detrimental, as selfish variants may be selected for and disrupt the integrity of the individual level.
• The study did not conclude to achieve a generalized autosomal average of the country; but rather, the existence of genetic heterogeneity among differing sample regions.
• Genetic heterogeneity and population ethnicity are also major limitations as they may increase the number of false positive and false negative findings which will make the identification of candidate genes more difficult.
• This resulted in a profound progress towards an etiological differentiation of the catatonic psychoses, which finally demonstrated a confirmed and significant linkage of periodic catatonia to chromosome 15q15, despite considerable genetic heterogeneity.
• It enabled progress into the molecular causes of the disorder and collagen mutations . ( Sillence DO, Senn A, Danks DM ( 1979 ) . " Genetic heterogeneity in osteogenesis imperfecta ".
• When TAAD occurs in the absence of syndromic features, it is inherited in an autosomal dominant manner with decreased penetrance and variable expression, the disease is referred to as familial TAAD . Familial TAAD exhibits significant clinical and genetic heterogeneity.
• Recalling Haldane s model, these sources of are generally classified as 1 ) genetic variation in the major locus 2 ) other sources of genetic heterogeneity, which include but are not limited to modifier genes, and 3 ) environmental influences.
• Characterization of the metabolic disorder, phenylketonuria ( PKU ) represents a progression from an initial biochemical discovery that informed genetic studies and led to an understanding that genetic heterogeneity within a major locus, and in addition to it, was responsible for variation in clinical phenotypes.
• Translocation as a tool is used to reduce the risk of a catastrophe to a species with a single population, to improve genetic heterogeneity of separated populations of a species, to aid the natural recovery of a species or re-establish a species where barriers might prevent it from doing so naturally.
• The principal challenges are : ( 1 ) most complex diseases involve small or weak contributions from multiple genetic factors that explain only a minuscule fraction of the population variation attributed to genetic factors . ( 2 ) Biological data is inherently extremely noisy, so the underlying complexities of biological systems ( such as linkage disequilibrium and genetic heterogeneity ) need to be incorporated into the statistical models for disease association studies.